NEWS
September 2024
Congrats to Elizabeth Zicari!
Elizabeth worked as a grad student in Pharmacy at the Transplant Surgery Research in 2024. Elizabeth successfully defend her Doctor of Pharmacy thesis and has entered the next step of her journey, starting Medical School at Université Paris Cité.
September 2024
Congratulations to Drs. Tullius and Martin, for receiving 2024 TTS International Mentee-Mentor Award for the work titled ‘Re-assessing the Determination of Sensitization Status in Kidney Transplant Candidates: Unveiling persistent Anti-HLA Antibodies in waitlisted Patients’.
August 2024Congratulations to our alumnus, Dr. Jasper Iske, for receiving the Young Investigator Award from the German Transplantation Society for his work with us, titled ‘Transplanting Old Organs Promotes Senescence in Young Recipients’.
May 2024
Congratulations Dr. Tullius! Dr. Tullius will take on the role as Editor-in-Chief of the Transplantation journals (Transplantation and Transplantation-Direct) on January 1st, 2025, with a transition period starting on July 1st, 2024.
Congratulations Freddy! At the 141st German Surgical Congress (DCK), Dr. Friederike Martin received the Fritz Linder Prize 2024 of the German Society of Surgery!
The Forum Prize is awarded to the first author of the best presentation within the Surgical Forum. Friederike was honored for her work “Aging is transferable: Old Organs Accelerate Aging and Induce Senescence in Young Recipients“.
October 2023
Congratulations Markus! At 32nd Annual Meeting of the German Transplantation Society (DTG). Dr. Markus Quante was rewarded with the 2023 Rudolf Pichlmayr Prize by the German Transplant Society – the most prestigious Transplant award in Germany.
Markus has been working with us from 2013 to 2016. He is now the managing senior attending, and Associate Professor of Surgery at the Medical School in Hannover, Germany.
May 2023
Congratulations Yao! Dr. Yao Xia received the ONE LAMBDA THERMO FISHER FELLOWSHIP AWARD, Women in Transplantation Research Fellowship Grant for Research titled as Exploring biological sex in organ transplantation.
Congratulations Yao! Yao Xiao, MD received the Women in Transplantation (WIT) Congress Scientific Award at 2022 International Transplantation Science Meeting.
June 2022Congratulations Jasper! Congratulations to Dr. Jasper Iske on receiving European Exploratory Research Grant by the European Society for Clinical Investigation, 2022.
May 2021Congratulations Freddy! Dr. Friederike Martin received the Sanofi Women in Transplantation Research Fellowship Grant for Research in Gender and Sex in Transplantation from Women in Transplantation.
May 2021
Congratulations to our alumni Dr. Jasper Iske, who was honored with the Young Talent Award of the German Surgeon Society for his work in the Tullius lab.
TALKS
International Congress of The Transplantation Society (TTS) 2024
- Accelerated Aging as a Novel Concept Driving Chronic Allograft Deterioration, Dr. Tullius Stefan.
- Benefits of investigating sex/gender for my research project, Dr. Friederike Martin.
- Re-assessing the Determination of Sensitization Status in Kidney Transplant Candidates: Unveiling persistent Anti-HLA Antibodies in waitlisted Patients, Dr. Friederike Martin.
- Delineating the Role of Biological Sex in Organ Transplantation: Identifying Estrogen Receptor α enhanced 4-1BB signaling as a critical component of T cell-mediated alloimmunity, Dr. Friederike Martin.
- Panel Reactive Antibody Levels decline with increasing Age: Potential of augmented Organ Availability and improved Outcomes for sensitized older Recipients, Merih Gizlenci.
American Transplant Congress (ATC) 2024
- Biological sex drives alloimmune responses through estrogen receptor α enhanced 4-1BB signaling in T cells, Yao Xiao.
- Chronic rejection represents a process of accelerated aging successfully treated with a combinational application targeting senescent cells and fibrotic pathways, Yao Xiao.
- A single cell analysis delineating the effects of biological sex of alloimmunity in organ transplantation, Yao Xiao.
- Senolytic treatment prevents chronic rejection of mouse cardiac allografts, Hao Zhou.
- Sex hormone-specific DC and T cell interactions in alloimmunity, Yao Xiao.
- Sex hormones impact transplant outcomes through a modified Dendritic (DC) – T Cell communication, Friederike Martin.
- Chronic rejection represents a process of accelerated aging that can be treated with the depletion of senescent cells (SCs) and their senescence-associated secretory phenotype (SASP), Friederike Martin.
- Organ aging and the potential of rejuvenation, Jasper Iske.
- State-of-the-Art session: The impact of sex hormones on transplant outcomes, Friederike Martin.
- Age vs. Frailty in Organ Transplantations, Maximilian Julius Roesel.
- Sex hormone-specific DC and T Cell interaction in alloimmunity: a single cell analysis, Yao Xiao.
- Critical role of accelerated senescence in driving chronic allograft dysfunction, Tomohisa Matsunaga.
- Transplanting old organs accelerates aging in young recipients, Andreas Schroeter.
GRANTS
2020-2025 NIH
Senescent Cells Drive mt-DNA Accumulation and Inflamm-aging
Research Grant #: R01AG064165-01A1
Role: PI
The major goals of this project are to dissect pathways driving augmented immunogenicity and compromised repair in old organs. We are prepared to investigate, in-depth, novel and age-specific therapies that will facilitate the utilization and optimize outcomes of older organs in transplantation
The KAPP-Sen Tissue Mapping Center Collaborative
Research Grant #: U54AG075941-01
Role: Co-Investigator/Site PI
The major goal is to enhance understanding of the role of senescent cells in aging and chronic diseases. Dr. Tullius will serve as the co-lead of the biorepository core and will provide the consortium with advice on clinical assessment, tissue collection, storage and shipment, and will provide the consortium with samples of kidney, fat and skin from healthy living donors with a representative distribution of gender and age. 2023–2027
Pablo and Almudena Legorreta Kidney Health Research Fund:
Moving Organ Rejuvenation into Clinical Application
Role: PI 2024-2029 Hevolution Foundation
Delineating the Interference of Cellular Senescence in Organ Transplantation
Research Grant #: HF-GRO-23-1199238-25
Role: PI
Senescence critically drives immunogenicity and chronic graft deterioration while molding alloimmunity. The major goals of this project are to define mechanisms of these processes and targeting senescent cells has the potential to significantly improve organ utilization and transplant outcomes. 2024-2029 NIH
Program Project Grant: Aging and Transplant Immunity, Project 2: Mechanisms and Novel Targets of T-Cell Immunity in Aging
Role: Project Leader
Research Grant #: P01AI175397-02
The major goals of this project are to investigate how aging rewires alloimmunity with critical effects on allorecognition, DC/T cell interaction, and T cell metabolism. We will provide novel opportunities for a refined immunosuppression in older recipients. 2024 SBIR/STTR Phase I, NSF
Non-Invasive Focused Ultrasound Treatment to Modulate the Immune System for Acute and Chronic Kidney Rejection
Role: Co-PI
Research Grant #: 2312694
This project aims to develop an external system for reducing inflammatory responses thereby reducing adverse events associated with the transplant and extending the lifetime of the new organ.